The versatile AMG 4.0-litre twin-turbo V8 engine in the E 63 S 4MATIC+ takes peak performance to a new level at 450 kW (612 hp). Maximum torque attains a new best value of 850 Nm. It is available over a broad engine speed range of 2500 to 4500 rpm and so provides a feeling of effortless superiority in every accelerator pedal position. A sprint from zero to 100 km/h is absolved in 3.4 seconds, and this dynamic acceleration only ends at the governed top speed of 250 km/h (with AMG Driver's package: 300 km/h).

Two twin-scroll turbochargers are deployed for the first time to boost performance and improve responsiveness further.